Senior Scientist, Biologics Expression Team
AstraZeneca

Job Info

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Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

We are seeking a skilled and highly motivated Scientist to enhance our Biologics Expression Team (BET) capabilities of biologics. The successful candidate will play a critical role in a dynamic group responsible for transient expression & purification of antibody therapeutics on a milligram-to-gram scale for not only normal IgG format also complex bispecific and multi-specific antibody. The selected individual will be a well-organized and a highly productive scientist that can design and execute experiments efficiently, as well as analyze, interpret and present data to multidisciplinary project teams

• Collaborate and work with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects.
• Execute cloning, production and purification of protein therapeutics from mammalian expression systems.
• Biochemical, biophysical and functional profiling of antibodies and recombinant antibody fragments.
• Ability to solve process development problems and implement improved procedures.
• Keep detailed and organized records of experiments

Basic Qualifications:

BS and 10+ years of relevant hands-on antibody expression and purification experience in either biotech/pharma industry or academia

OR MS and 8+ years of experience

OR PhD in life sciences with preference in Molecular Biology, Immunology or a related field.and 2+ years or experience.

Required Skills

• Extensive hands-on experience in molecular biology and protein engineering, including; design, expression, purification and biochemical/biophysical characterization of various antibody formats.
• Experience in molecular and cell biology techniques including; gene synthesis design, primer design, gene assemblies and cloning, transfection and transduction methods.
• Expression recombinant antibodies in transient expression systems using mammalian cells; purification of recombinant proteins and antibodies using affinity-based and/or conventional chromatographic separation techniques; use of automated purification platforms including AKTA.
• Biochemical/biophysical characterization of various antibody formats using ion exchange, analytical SEC, endotoxin analysis, immunoblotting, or related techniques.
• Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines.
• Demonstrated ability to influence and build strong relationships with internal and external collaborators while working effectively in a collaborative team environment across multiple functions.
• Strong problem solving, organizational skills, risk management and orientation to detail.
• Excellent written and verbal communication skills and effective presentation to cross-functional and senior management teams are essential for this role.

Preferred Qualifications:

• Experience in antibody discovery using several cloning technologies.
• Experience in various imaging/multicolor flow cytometry-based instruments and data analysis programs.
• Experience in tissue culture techniques and functional cell-based assay development.
• Strong interpersonal and communication skills as well as the ability to work within teams.
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management.

Summary of the Group

Biologics Engineering (BE) is responsible for the discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases. We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for the development of in-house biologics discovery platforms and novel drug modalities to address unmet medical needs.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering innovative methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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