Massachusetts Eye and Ear is an international center for treatment and home to the world's largest vision and hearing research centers. Mass. Eye and Ear is a member of Mass General Brigham and a teaching hospital of Harvard Medical School.
Mass. Eye and Ear clinicians are driven by a mission to find cures for blindness, deafness and diseases of the head and neck. Internationally acclaimed since its founding in 1824, Mass. Eye and Ear employs full-time, board-certified physicians who offer high quality and affordable specialty care that ranges from the routine to the very complex. Learn more about our Mission, Vision and Values and Diversity, Equity and Inclusion on our site.
Providing a safe environment for everyone is the core tenet of our Safe Care Commitment. Across Mass General Brigham, employees are doing their part to ensure that the hospitals, clinics, practices and office spaces across our system are safe and ready.
Mass. Eye and Ear physicians are located at our main campus in Boston, and at our suburban locations in the greater Boston and Providence areas, across 21 locations.
We are seeking a talented postdoctoral fellow to join our team to study the pathogenesis of
inherited retinal degenerations (IRDs). IRDs are important causes of vision loss that affect people of all ages. Mutations in over 270 genes required for photoreceptor and retinal pigment epithelial (RPE) cell function have been identified as IRD disease genes. Genetic therapies show great promise for reducing or preventing vision loss from IRDs and clinical trials are in progress for multiple genetic forms of IRD.
A subset of genetic forms of IRD are caused by mutations in genes that encode components of the spliceosome. We hypothesize that in these RNA splicing factor forms of IRD, RNA splicing is altered specifically in the retina and/or RPE, leading to retinal degeneration. Evidence from studies performed to date using animal and cell-based models of disease support this hypothesis, and provide a strong basis for mechanistic studies of disease pathogenesis.
We are looking for an energetic postdoc to join our NIH-funded project to investigate the molecular pathogenesis of RNA splicing factor forms of IRD. These studies will focus on using human induced pluripotent stem cell (hiPSC) derived RPE cells and retinal organoids to investigate disease pathogenesis via multiple methods, including CRISPR-mediated perturbation studies. We anticipate the results of these studies will provide insight into retinal biology, and identify pathways that could be targeted for therapies of these genetic forms of IRD.
Qualified candidates should have strong cell and molecular biology skills, and be able to work independently as well as in a group environment. This position offers an excellent opportunity to learn and apply skills in molecular biology, genomics and evaluation of hiPSC-derived models of retinal disease. Experience in one or more of these areas is preferred.
Requires a Masters and/or Ph.D in their field of specialty. 1 to 5 years experience preferred.
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