Associate Scientist II, Plasmid Production
AstraZeneca

Job Info

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This is what you will do:

We are seeking a highly motivated and skilled individual to join our team as an Associate Scientist II - Plasmid Production. The ideal candidate will have a strong background in molecular biology and hands-on experience in plasmid production and purification techniques. The role will involve executing manufacturing protocols, maintaining equipment, and ensuring the quality and efficiency of plasmid manufacturing processes. This position offers an exciting opportunity to contribute to the production of key molecular biology reagents essential for the production of AAV vectors to be used for Alexion's Rare Disease Gene Therapy Research.

You will be responsible for:

• Candidates should be capable of executing and documenting plasmid DNA scale up protocols with highly reproducible results in an efficient and timely manner.
• Tasks include, but are not limited to, bacterial transformation and culture, plasmid DNA purification (minipreps, gigapreps), and plasmid quality control (restriction digest, endotoxin readings, quality readings, and NGS/Sanger sequencing).
• Generation of reports, SOPs, and quality documents (Certificate of Analysis and batch records). Accurate and detailed documentation of sample records is critical using systems such as electronic lab notebooks.
• General laboratory operations - Maintaining inventories, monitoring/calibrating/cleaning equipment. Check stocks of required consumables enabling DNA preps (Plasmid preparation kits, enzymes, etc)
• Transfer of liquid and solid waste to appropriate collection containers as indicated per SOP
• Sharing data/results in group settings and larger organizational meetings
• Maintain lab and desk space cleanness
• Identify and report quality or compliance concerns to management and quality function and take immediate actions to remedy

You will need to have:

• Bachelors degree in a related scientific field, OR equivalent years of experience in biopharmaceutical industry.
• Minimum of one year experience wet bench experience, preferably working in plasmid prep production
• Excellent research task oversight skills including adherence to procedures, best practices and detailed documentation/record keeping
• Superior organizational and time management skills, ability to prioritize multiple demands and work efficiently under pressure
• Excellent oral and written communication skills
• Demonstrated ability to utilize standard office software (Excel, Powerpoint, Word, etc) or other Project Management/eNotebooks software.
• The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to lift 15 pounds unassisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We would prefer for you to have:

• Experience with plasmid prep, including mini & gigapreps, as well as bacterial fermentation.
• Familiar with Molecular Biology protocols; transformations, colony picking, bacterial culture, and DNA quantification using instrumentation

In-person statement for 4 days in the office:
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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